Organometallic Compounds
Medchemexpress LLC Mangafodipir trisodium | 140678-14-4 | 99.7% | 100 MG
Mangafodipir trisodium (MnDPDP) is a hepatocellular-specific contrast agent and an efficacious inhibitor of chemotherapy-induced peripheral neuropathy (CIPN) and other conditions caused by cellular oxidative stress. It does not negatively interfere with the tumoricidal activity of chemotherapy.
- Inhibits effect of HGrC cell viability caused by H2O2
- Attenuates apoptosis caused by cisplatin in HGrC cells
- Shows protective effects against ovarian damage caused by cisplatin and paclitaxel in mice
Frontier Specialty Chemicals 1G POTASSIUM TRIFLUORO(TRIFLUO
This item has a minimum qty of 2 per supplier requirements.
1g Potassium Trifluoro(trifluo. 42298-15-7
Medchemexpress LLC Bromoacetamido-PEG3-azide | 940005-81-2 | ≥97.0% | C10H19BrN4O4 | 50 MG
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent containing an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC Iron II D-gluconate 100g
Iron(II) D-gluconate dihydrate 98% is used for blood coagulation
Medchemexpress LLC M-PEG3-Aminooxy | 248275-10-7 | 98.0% | C7H17NO4 | 250 MG
m-PEG3-Aminooxy is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two distinct ligands linked together: one designed to bind to an E3 ubiquitin ligase and the other to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC NH-bis(PEG3-azide) | 1258939-39-7 | 98.0% | C16H33N7O6 | 250 MG
NH-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Functions as a click chemistry reagent
- Contains an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Capable of strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC 5-Bromo-2-trifluoromethylpyridine | 436799-32-5 | MFCD06657686 | 99.7% | C6H3BrF3N | 25 G
5-Bromo-2-trifluoromethylpyridine is a biochemical reagent primarily for life science research. It functions as a biological material or organic compound, supporting various research applications. This product is strictly for research use and not intended for patient use.
- Biochemical reagent for life science research
- Can be used as a biological material or organic compound
- Molecular weight: 225.99
- Appearance: Solid
- Color: White to off-white
- Purity: 99.7%
- For research use only
Medchemexpress LLC Tolterodine (tartrate) | 124937-52-6 | MFCD00045558 | 98.6% | C26H37NO7 | 250 MG
Tolterodine tartrate is an mAChR inhibitor and substrate for cytochrome P450 enzymes, used in research for urinary tract infections and overactive bladder. It competitively binds acetylcholine, reducing sympathetic excitation and inhibiting involuntary bladder muscle contraction.
- Inhibits muscarinic acetylcholine receptors
- Substrate for cytochrome P450 enzymes
- Reduces sympathetic excitation
- Inhibits involuntary bladder muscle contraction
- Restores Nrf2/NF-κB signaling pathway
- Protects against inflammatory response and ferroptosis
- Ameliorates LPS-induced oxidative stress
Medchemexpress LLC Trimethylsilyl trifluoromethylsulfonate | 27607-77-8 | 98.0% | 222.26 | 100 G
Trimethylsilyl trifluoromethylsulfonate is classified as a biological molecule.
- Intended for research use only.
- Not sold for patient use.
- Functions as a biochemical assay reagent.
Medchemexpress LLC ABT-639 | 1235560-28-7 | 99.3% | 455.91 | 5 MG
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. It is for research use only and not sold to patients.
- Novel, peripherally acting, selective T-type Ca2+ channel blocker.
- Blocks recombinant human T-type (Cav3.2) Ca2+ channels (IC50=2 μM).
- Attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM).
- Less active at other Ca2+ channels (e.g., Cav1.2, Cav2.2) (IC50>30 mM).
- High oral bioavailability (%F=73), low protein binding (88.9%), low brain:plasma ratio (0.05:1) in rodents.
- Produces dose-dependent antinociception in rat model of knee joint pain (ED50=2 mg/kg, p.o.).
- Increases tactile allodynia thresholds in multiple models of neuropathic pain (10-100 mg/kg, p.o.).
- Does not attenuate hyperalgesia in inflammatory pain models.
- Does not significantly alter hemodynamic or psychomotor function at higher doses (e.g., 100-300 mg/kg).
Medchemexpress LLC Biotin-PEG3-SS-azide | 2866429-93-6 | 99.6% | 692.91 | C27H48N8O7S3 | 10 MG
Biotin-PEG3-SS-azide is a cleavable three-unit polyethylene glycol linker bearing a biotin group and a terminal azide, designed for conjugation chemistry in research applications. It is suitable for click chemistry reactions and as a cleavable linker in the synthesis of antibody-drug conjugates.
- Cleavable disulfide linker provides intracellular release.
- Azide functionality enables CuAAC and strain-promoted cycloaddition.
- PEG3 spacer increases solubility and reduces steric hindrance.
- High purity supports reliable conjugation results.
- Soluble in DMSO at high concentration for in vitro use.
- Recommended storage at low temperature and protection from light to preserve stability.
Medchemexpress LLC Tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate | 252881-73-5 | 303.3547 g/mol | C13H25N3O5 | 50 MG
N3-PEG3-CH2CH2-Boc is an azido-terminated PEG3 linker with a tert-butyl (Boc) protected carboxylic acid end, used as a cleavable PEG-based linker in antibody-drug conjugate and PROTAC synthesis, and as an azide reagent for click chemistry.
- Azide-terminated PEG3 linker suitable for click chemistry.
- tert-Butyl (Boc) protected carboxyl end for orthogonal deprotection.
- Used in ADC and PROTAC linker assembly.
- Available as a small pre-weighed laboratory pack for synthetic use.
Medchemexpress LLC 5,8,11-trioxa-2-azatetradecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 1 G
Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected PEG3 linker bearing a terminal carboxylic acid, used in research applications as a cleavable linker for antibody-drug conjugates and as a PEG-based linker for PROTAC synthesis.
- Fmoc-protected amine functionality for standard peptide chemistry
- Terminal carboxylic acid for conjugation
- High reported purity (≈99.8%)
- Molecular weight 443.49 g/mol
- Chemical formula C24H29NO7
- Available in small-scale quantities, including 1 G